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pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can minimize panobinostat concentrations by ~70% and bring on treatment failure.pentobarbital will minimize the extent or outcome of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caut